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However, after a large dose of APAP, the sulfonation reaction becomes saturated and the build-up of NAPQI depletes GSH in the liver, causing further accumulation of NAPQI

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Exposure to toxins can increase oxidative stress, leading to a decline in glutathione levels

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This limits the proliferation of Enterococcus and Klebsiella pneumoniae , while also inhibiting excessive growth of Escherichia coli through the induction of antimicrobial peptides