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This weakens the Notch3-mediated downstream signaling pathway, inducing glioma cell death and indicating that ChaC1 can influence the cytotoxicity of tumor cells induced by temozolomide (69)

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Hormone and metabolic modulators

This range derives from animal study scaling calculations and has become the standard starting point

From this it can be deduced that nanobodies must have the following properties to neutralize: (1) binding to prefusion gB, with (2) sufficient affinity and (3) weaker binding to postfusion, resulting in a change in Gibbs free energy that forms an energy barrier that is sufficient to hold gB in prefusion conformation