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What Happens: GLP-1 medications cross the blood-brain barrier Activate receptors in appetite control regions Reduce hunger signals Increase satiety (feeling of fullness) Decrease reward response to food Reduce obsessive thoughts about food What You Experience: Less frequent hunger Feel satisfied with smaller portions Dont think about food constantly Reduced cravings for specific foods Easier to say no to unnecessary eating This is the primary mechanismyou naturally eat less because you genuinely want less food
These trials need to incorporate pharmacogenomic endpoints to identify patients most likely to benefit, as exemplified by nutrigenomics studies linking VDR polymorphisms to vitamin D efficacy in prostate cancer
After propensity matching for age, sex, race, and obesity, 69,221 patients were included in the primary analysis
Diabetes 58 , 28202827 (2009)
doi: 10.2217/fnl.11.55 Drucker DJ
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