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Copper itself is an essential cofactor for numerous enzymes involved in collagen synthesis (lysyl oxidase), antioxidant defense (superoxide dismutase) and melanin production (tyrosinase)

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Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues

They can be helpful in the short term for things like jet lag or an occasional rough night

DSIP is found endogenously in the hypothalamus, limbic system, pituitary gland, and several peripheral organs, a distribution pattern that suggests biological roles extending well beyond sleep alone