Representative immunohistochemical staining of TNF-, Caspase-1, NLRP3, fibronectin, collagen I, and -SMA in renal tissue of mice in each group was performed
However, at closer inspection, these reactions were more likely caused by the (concomitant) use of angiotensin-converting enzyme inhibitors or an infection (130)
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If these findings translate into significant reductions in hard clinical endpointsparticularly cardiovascular events, kidney outcomes, and mortalityretatrutide has the potential to become a truly transformative therapy, not just another weight-loss drug