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Therefore, targeting mitochondrial Ca 2+ handling is of great therapeutic potential

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Activated microglia inflict damage on oligodendrocytes through the release of pro-inflammatory cytokines such as IL-1, IL-6, TNF-, and interferons, alongside phagocytic activity, and antigen presentation to CD 4+ T cells via MHC class II [270]

MTHFR, or the methylenetetrahydrofolate reductase is the key regulatory enzyme in folate and homocysteine metabolism

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