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HCV infection is strongly associated with mitochondrial ROS overproduction, driven by impaired electron flow in ETC complexes I and III and augmented calcium influx into mitochondria (Medvedev et al., 2016)
doi: 10.1038/KI.1980.179 47 EgleK.DohleE.HoffmannV.SalmaI.Al-MaawiS.GhanaatiS.et al
It also elevated the level of antioxidant enzymes
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Alternatively, Hcy combines with serine to form cystathionine, catalyzed by the enzyme cystathionine beta-synthase (CBS) and vitamin B6
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