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The American Diabetes Associations 2025 standards place GLP-1 receptor agonists immediately after metformin for high-risk patients, expanding the eligible pool by roughly 12 million adults [1]American Diabetes Association, Standards of Care 2025, diabetes.org
Definition increases as both intermuscular and subcutaneous fat continue decreasing
Ibrahim NE, Gaggin HK, Turchin A et al (2019) Heart rate, beta-blocker use, and outcomes of heart failure with reduced ejection fraction
Half-life extends from ~10 minutes (native) to ~6 hours (LR3)
The committee will evaluate historical safety data, adverse event reports, and clinical utility to decide if they should be moved to Category 1
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